Magnesium Sulfate Heptahydrate USP Granular

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• Cochrane Database Syst Rev. 2007 Jul Magnesium sulfate for persistent pulmonary hypertension of the newborn

  Background: Persistent pulmonary hypertension of the newborn (PPHN) occurs in approximately 1.9 per 1000 newborns and may be more frequent in developing countries. There is strong evidence for the use of inhaled nitric oxide (iNO) and extra corporeal membrane oxygenation (ECMO) in the treatment of PPHN. However, many developing countries do not have access or the… Read Abstract

• BJOG. 2018 Sep Is there benefit to continue magnesium sulphate postpartum in women receiving magnesium sulphate before delivery? A randomised controlled study

  Objective: To determine if the use of magnesium sulphate postdelivery reduces the risk of eclampsia in women with severe pre-eclampsia exposed to at least 8 hours of magnesium sulphate before delivery. Design: Randomised multicentre controlled trial. Setting: Latin America. Population: Women with severe pre-eclampsia that had received a 4-g loading dose followed by 1 g per hour for 8… Read Abstract

• Eur J Clin Pharmacol. 2017 Mar Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma

  Purpose: Intravenous (IV) magnesium sulfate (MgSO4) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. Methods: To explore the pharmacokinetics (PK) of IV MgSO4 in this population, we collected retrospective data from 54 children who received IV MgSO4 for treatment of an… Read Abstract

• Arch Dis Child Fetal Neonatal Ed.. 2015 Nov Antenatal magnesium sulfate: Neuro-protection for preterm infants

  The neuro-protective effect of antenatal magnesium sulfate on very preterm infants has been demonstrated in good-quality randomised controlled trials and meta-analyses. Magnesium administered prior to preterm delivery crosses over to the foetal circulation and acts via several pathways to reduce perinatal neuronal damage. Meta-analysis of the trial data indicates that antenatal magnesium sulfate reduces the… Read Abstract

• Magnes Res. 2005 Sep Magnesium chloride or magnesium sulfate: a genuine question

  MgSO4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO4 and MgCl2 effects in order to answer the question whether MgSO4 could be or not replaced by MgCl2. Considering that the two salts have both similar and proper effects, a clear-cut conclusion is not easy to… Read Abstract

• Cochrane Database Syst Rev . . 2010 Nov Magnesium sulphate and other anticonvulsants for women with pre-eclampsia

  Background: Eclampsia, the occurrence of a seizure (fit) in association with pre-eclampsia, is rare but potentially life-threatening. Magnesium sulphate is the drug of choice for treating eclampsia. This review assesses its use for preventing eclampsia. Objectives: To assess the effects of magnesium sulphate, and other anticonvulsants, for prevention of eclampsia. Search strategy: We searched the Cochrane Pregnancy and… Read Abstract

• J Obstet Gynaecol Can. 2019 Apr No. 376-Magnesium Sulphate for Fetal Neuroprotection

  Objective: The objective is to provide guidelines for the use of antenatal magnesium sulphate for fetal neuroprotection of the preterm infant. Options: Antenatal magnesium sulphate administration should be considered for fetal neuroprotection when women present at ≤33 + 6 weeks with imminent preterm birth, defined as a high likelihood of birth because of active labour with cervical… Read Abstract

• British Journal of Anaesthesia. 2013 May Effect of intrathecal magnesium in the presence or absence of local anaesthetic with and without lipophilic opioids: a systematic review and meta-analysis.

  Spinal anaesthesia is the primary anaesthetic technique for many types of surgery. Adjuncts to the local anaesthetics (LA) used in spinal anaesthesia can exhibit undesirable side-effects, limiting their use, but magnesium may have advantages in this respect. We sought randomized control trials (RCTs) in patients undergoing all types of surgery and in women in labour… Read Abstract

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