Jost Chemical Increases Manufacturing Capacity of Permeation Enhancement Compounds Sodium Caprate and Sodium Caprylate
Jost Chemical is pleased to announce an enhanced supply of sodium caprate (C10) and sodium caprylate (C8).
Sodium caprate is one of the most studied permeation enhancement compounds for improving oral absorption of compounds with poor intestinal permeability. It is common that peptides, structurally similar non-peptides, and other types of macromolecules or hydrophilic small molecules, have poor intestinal permeability, low oral bioavailability and rapid enzymatic or pH-induced degradation in the gastrointestinal tract.
Sodium caprate is known to enhance bioavailability by “loosening” the tight junctions between cells in the intestinal lining, which allows compounds to pass more easily through the cell membranes and into the bloodstream. This can lead to higher concentrations of an active pharmaceutical ingredient (API) or nutrient in the bloodstream and can therefore yield improved therapeutic or nutritional effects.
“Bioavailability and efficacy of API’s are key factors for products in the marketplace,” Joe Hardimon, Global Research Director of Jost Chemical, stated. “We see continued growth in permeation enhancement and are ready for increased demand.”
Jost Chemical offers two permeation enhancement compounds, Sodium Caprate and Sodium Caprylate for tablet, capsule, and pre-mix preparations. Both products are Halal and Kosher certified.
“Although we’ve seen these permeation enhancement compounds primarily used in the pharmaceutical industry, we’ve recently noticed further exploration of permeation enhancement in the nutritional and cosmetic industries,” added Hardimon.
For more information view our Permeation Enhancer brochure.
With 35 years of experience, Jost Chemical manufactures high-purity mineral salts in St. Louis, Missouri and Koscian, Poland. Jost products are fully reacted, consistent from lot-to-lot and meet and typically exceed customer requirements. Packaging options include fiber drums, fiber cartons, poly drums, plastic pails, and bulk super sacks. Jost offers customized particle sizes from free-flowing granular to ultrafine (< than 6 microns) powders.