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Home › Related Articles › Page 14

Related Articles

Eur J Clin Pharmacol. 2017 Mar

Clinical pharmacokinetics of magnesium sulfate in the treatment of children with severe acute asthma

Purpose: Intravenous (IV) magnesium sulfate (MgSO4) is used as adjunct therapy to treat acute asthma exacerbations. Despite its clinical use, there is a limited understanding of the disposition of magnesium in children. Methods: To explore the pharmacokinetics (PK) of IV MgSO4 in this population, we collected retrospective data from 54 children who received IV MgSO4 for treatment of an…
Arch Dis Child Fetal Neonatal Ed.. 2015 Nov

Antenatal magnesium sulfate: Neuro-protection for preterm infants

The neuro-protective effect of antenatal magnesium sulfate on very preterm infants has been demonstrated in good-quality randomised controlled trials and meta-analyses. Magnesium administered prior to preterm delivery crosses over to the foetal circulation and acts via several pathways to reduce perinatal neuronal damage. Meta-analysis of the trial data indicates that antenatal magnesium sulfate reduces the…
Magnes Res. 2005 Sep

Magnesium chloride or magnesium sulfate: a genuine question

MgSO4 is routinely used in therapeutics despite its toxicity. The aim of the present review was to compare MgSO4 and MgCl2 effects in order to answer the question whether MgSO4 could be or not replaced by MgCl2. Considering that the two salts have both similar and proper effects, a clear-cut conclusion is not easy to…
Cochrane Database Syst Rev . . 2010 Nov

Magnesium sulphate and other anticonvulsants for women with pre-eclampsia

Background: Eclampsia, the occurrence of a seizure (fit) in association with pre-eclampsia, is rare but potentially life-threatening. Magnesium sulphate is the drug of choice for treating eclampsia. This review assesses its use for preventing eclampsia. Objectives: To assess the effects of magnesium sulphate, and other anticonvulsants, for prevention of eclampsia. Search strategy: We searched the Cochrane Pregnancy and…
J Obstet Gynaecol Can. 2019 Apr

No. 376-Magnesium Sulphate for Fetal Neuroprotection

Objective: The objective is to provide guidelines for the use of antenatal magnesium sulphate for fetal neuroprotection of the preterm infant. Options: Antenatal magnesium sulphate administration should be considered for fetal neuroprotection when women present at ≤33 + 6 weeks with imminent preterm birth, defined as a high likelihood of birth because of active labour with cervical…
Biologicals. 2010 Mar

Validation of a simple, rapid and cost effective method for the estimation of caprylic acid and sodium caprylate from biological products using NEFA-C kit

The method for the determination of caprylic acid and sodium caprylate from biological products was systematically validated using NEFA-C kit. The results obtained demonstrated that the kit method was simple, rapid, reliable, sensitive, reproducible and cost effective in comparison to the current methods i.e. colorimetric, High Performance Liquid Chromatography (HPLC) and Gas Chromatography (GC) methods.…
AAPS PharmSciTech. 2014 Apr

The role of caprylate ligand ion on the stabilization of human serum albumin

Sodium caprylate was added to a pharmaceutical-grade human serum albumin (HSA) to stabilize the product. In this study we have aimed to establish how caprylate ligand protects HSA from thermal degradation. The fatty acid stabilizer was first removed from commercial HSA by charcoal treatment. Cleaned HSA was made to 10% w/v in pH 7.4 buffered…
Am J Vet Res. 2011 Mar

In vitro antimicrobial properties of caprylic acid, monocaprylin, and sodium caprylate against Dermatophilus congolensis

Objective: To determine antimicrobial effects of caprylic acid and its derivatives, monocaprylin and sodium caprylate, on Dermatophilus congolensis and to determine effects of caprylic acid on the ultrastructure of D congolensis by use of transmission electron microscopy (TEM). Sample: 3 strains of D congolensis (33411, 33413, and 14639). Procedures: Strains of D congolensis were incubated separately under anaerobic…
J Food Prot. 2006 Sep

Inactivation of escherichia coli O157:H7 in cattle drinking water by sodium caprylate

Escherichia coli O157:H7 is an important foodborne pathogen. Cattle serve as one of the major reservoirs of E. coli O157:H7, excreting the pathogen in feces. Environmental persistence of E. coli O157:H7 is critical in its epidemiology on farms, and the pathogen has been isolated from cattle water troughs. Thus, there is a need for an…
Protein Expr Purif. 2019 Dec

Sodium caprylate induced precipitation post Protein A chromatography as an effective means for host cell protein clearance

In downstream processing of monoclonal antibody (mAb), post Protein A neutralization and subsequent intermediate depth filtration are critical steps for host cell protein (HCP) clearance. Previous studies have shown that adding caprylic acid (CA) during neutralization can further improve HCP removal by promoting their precipitation. In this study, we replaced CA with its sodium salt…
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