• About Us
    • Who We Are
    • Our History
    • Mission & Values
    • Why Choose Jost
  • Products
    • Ammonium
    • Calcium
    • Copper
    • Iron
    • Magnesium
    • Manganese
    • Potassium
    • Sodium
    • Strontium
    • Zinc
    • Ultra Pure Minerals (Low Heavy Metals)
    • Infant Pure (Low Chlorate Minerals)
    • Pharma Pure
    • JOSTCOTE® Microencapsulated
    • New Products
    • Custom Products
  • Our Expertise
    • cGMP Manufacturing
    • Quality
    • Research & Development
    • Customer Service
  • Markets
    • Nutritional
    • Pharmaceutical / Biotech
    • Specialty
  • Media
    • Library
    • News
    • Events
    • Videos
  • Technical Info
    • Technical Resources
    • Links
  • Contact Us
    • Sales & Customer Service
    • Our Locations
  • Careers
Jost Chemical Co.
  • FAQ
  • Download Catalog
  • 314-428-4300
  • About Us
    • Who We Are
    • Our History
    • Mission & Values
    • Why Choose Jost
  • Products
    • Ammonium
    • Calcium
    • Copper
    • Iron
    • Magnesium
    • Manganese
    • Potassium
    • Sodium
    • Strontium
    • Zinc
    • Ultra Pure Minerals (Low Heavy Metals)
    • Infant Pure (Low Chlorate Minerals)
    • Pharma Pure
    • JOSTCOTE® Microencapsulated
    • New Products
    • Custom Products
  • Our Expertise
    • cGMP Manufacturing
    • Quality
    • Research & Development
    • Customer Service
  • Markets
    • Nutritional
    • Pharmaceutical / Biotech
    • Specialty
  • Media
    • Library
    • News
    • Events
    • Videos
  • Technical Info
    • Technical Resources
    • Links
  • Contact Us
    • Sales & Customer Service
    • Our Locations
  • Careers
Home › Related Articles › Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives
Nanotoxicology. 2018 Sep

Quantitative human health risk assessment along the lifecycle of nano-scale copper-based wood preservatives

Abstract:

The use of nano-scale copper oxide (CuO) and basic copper carbonate (Cu2(OH)2CO3) in both ionic and micronized wood preservatives has raised concerns about the potential of these substances to cause adverse humans health effects. To address these concerns, we performed quantitative (probabilistic) human health risk assessment (HHRA) along the lifecycles of these formulations used in antibacterial and antifungal wood coatings and impregnations by means of the EU FP7 SUN project’s Decision Support System (SUNDS, www.sunds.gd). The results from the risk analysis revealed inhalation risks from CuO in exposure scenarios involving workers handling dry powders and performing sanding operations as well as potential ingestion risks for children exposed to nano Cu2(OH)2CO3 in a scenario involving hand-to-mouth transfer of the substance released from impregnated wood. There are, however, substantial uncertainties in these results, so some of the identified risks may stem from the safety margin of extrapolation to fill data gaps and might be resolved by additional testing. Our stochastic approach successfully communicated the contribution of different sources of uncertainty in the risk assessment. The main source of uncertainty was the extrapolation from short to long-term exposure, which was necessary due to the lack of (sub)chronic in vivo studies with CuO and Cu2(OH)2CO3. Considerable uncertainties also stemmed from the use of default inter- and intra-species extrapolation factors.

PMID 29893192  /  Danail Hristozov, Lisa Pizzol, Gianpietro Basei, Alex Zabeo, Aiga Mackevica, Steffen Foss Hansen, Ilse Gosens, Flemming R Cassee, Wim de Jong, Antti Joonas Koivisto, Nicole Neubauer, Araceli Sanchez Jimenez, Elena Semenzin, Vrishali Subramanian, Wouter Fransman, Keld Alstrup Jensen, Wendel Wohlleben, Vicki Stone, Antonio Marcomini

Related Products
  • Library
  • News
    • Company News
    • Product Development
    • Industry News
    • Awards
  • Events
  • Videos

Learn about new Jost products and events.
subscribe

  • Who We Are
  • Products
  • Documents
  • News
  • Contact
  • Careers
  • Spanish
  • German
  • French

Follow Us

  • linkedin
  • facebook

Jost Chemical Co.
(The Americas and Asia)
8150 Lackland
St. Louis, MO 63114
Tel: +1 314 428 4300
Fax: +1 314 428 4366
customer.service@jostchemical.comcustomer.service@jostchemical.com

Jost Chemical Poland sp. z o.o
(Europe, Middle East and Africa)
ul. gen. Kazimierza Pułaskiego 7
64-000 Kościan, Poland
Tel: +48 65 322 69 00
Fax: +48 65 322 69 06
customer.service@jostchemical.comcustserv@jostchemical.com

Sitemap     Cookies     Terms of Use

Copyright © 1995–2025 Jost Chemical Co. All rights reserved.