Related Articles
On Drug Delivery. 2015 Jan
Oral peptide delivery: Technology landscape & current status
In this review piece, Leila N Hassani, PhD, Scientist in the Novel Drug Delivery Technologies Group; Andy Lewis , PhD, Director of Novel Drug Delivery Technologies; and Joël Richard, PhD, Senior Vice-President, Peptides, all of Ipsen, provide an overview of the advantages provided, and challenges faced, by oral peptide delivery, and discuss the strengths and…
Pharmaceutics. 2019 Feb
Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)
Salcaprozate sodium (SNAC) and sodium caprate (C10) are two of the most advanced intestinal permeation enhancers (PEs) that have been tested in clinical trials for oral delivery of macromolecules. Their effects on intestinal epithelia were studied for over 30 years, yet there is still debate over their mechanisms of action. C10 acts via openings of epithelial…
Biomaterials. 2013 Jan
Sodium caprate as an enhancer of macromolecule permeation across tricellular tight junctions of intestinal cells
Sodium caprate is a promising candidate for inducing drug absorption enhancement. The mechanism of that uptake-enhancing effect is not fully understood so far. We investigated how caprate acts in an established human intestinal cell line, HT-29/B6, on the transient opening of transcellular (across the cell membranes) and paracellular (across the tight junction) pathways. Sodium caprate…
Therapeutic Delivery. 2011 Dec
Oral peptide delivery: prioritizing the leading technologies
In the late 1980s and early 1990s, oral delivery technologies for macromolecules, peptides and proteins mushroomed at tremendous rates due to a number of very promising preclinical studies. Interest from pharmaceutical companies in these technologies subsequently fell away from in the late 1990s owing to a series of clinical disappointments as many supposed ‘platform technologies’…
Tissue Barriers. 2017 Jul
Intestinal surfactant permeation enhancers and their interaction with enterocyte cell membranes in a mucosal explant system
Intestinal permeation enhancers (PEs) are agents aimed to improve oral delivery of therapeutic drugs with poor bioavailability. The main permeability barrier for oral delivery is the intestinal epithelium, and PEs act to increase the paracellular and/or transcellular passage of drugs. Transcellular passage can be achieved by cell membrane permeabilization and/or by endocytic uptake and subsequent…
J Agric Food Chem. 2002 Aug
Absorption of calcium fumarate salts is equivalent to other calcium salts when measured in the rat model
Calcium absorption from fumarate salts (calcium fumarate and calcium malate fumarate), which have recently been considered for use as sources for food and beverage enrichment, was compared to that from calcium citrate malate, calcium citrate, and calcium carbonate. Salts were instrinsically labeled with 45Ca and orally administered to Sprague-Dawley rats. Fractional absorption of calcium from…
Boll Chim Farm. 2003 Sep
Calcium concentration at rat females with osteoporosis after applying calcium fumarate
The dynamics of total calcium concentration in blood of rat females with osteoporosis caused experimentally after applying it in the form of fumarate was determined. The fumarate was applied in just one dose by the means of stomach tube at the dose of teoporoz_ 4.28 mg of calcium/100 g of body mass. The total calcium…
Inorg Chem. 2015 Dec
Mechanical Properties of a Calcium Dietary Supplement, Calcium Fumarate Trihydrate
The mechanical properties of calcium fumarate trihydrate, a 1D coordination polymer considered for use as a calcium source for food and beverage enrichment, have been determined via nanoindentation and high-pressure X-ray diffraction with single crystals. The nanoindentation studies reveal that the elastic modulus (16.7-33.4 GPa, depending on crystallographic orientation), hardness (1.05-1.36 GPa), yield stress (0.70-0.90…
J Nephrol. 2019 Nov
Control of metabolic predisposition to cardiovascular complications of chronic kidney disease by effervescent calcium magnesium citrate: a feasibility study
Aims: Cardiovascular (CV) complications are common in chronic kidney disease (CKD). Numerous metabolic disturbances including hyperphosphatemia, high circulating calciprotein particles (CPP), hyperparathyroidism, metabolic acidosis, and magnesium deficiency are associated with, and likely pathogenic for CV complications in CKD. The goal of this feasibility study was to determine whether effervescent calcium magnesium citrate (EffCaMgCit) ameliorates the aforementioned…
Gene. 2017 Mar